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The United States on Wednesday imposed sanctions on five Iranian companies and one individual for their alleged support of Iran’s nuclear program, the Treasury Department said.

The action targets entities linked to the Atomic Energy Organization of Iran (AEOI) and its subsidiary, the Iran Centrifuge Technology Company (TESA), both of which play key roles in Iran’s uranium enrichment and nuclear development efforts.

The Treasury’s Office of Foreign Assets Control (OFAC) designated the firms under Executive Order 13382, which aims to curb the proliferation of weapons of mass destruction.

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Jailed activist Mehdi Mahmoudian warned in a letter to Supreme Leader Ali Khamenei that public mistrust has left Iran too fractured to support any government stance in a possible future conflict or negotiations.

“If war breaks out, the enemy won’t need to attack from outside — you’ve sown hatred in hearts, and this land will collapse from within,” he wrote from Evin Prison.

Mahmoudian criticized Iran’s leadership for isolating the country and weakening national unity, saying: “From the families of those executed, to ethnic minorities whose languages are banned, to a youth fleeing the country — who do you expect to defend Iran?”

Mahmoudian dismissed both diplomacy and displays of strength as solutions: “Today, neither the JCPOA, nor negotiations, nor the illusion of power in your mind can save us. Only your unconditional retreat from power, handing it to the people, and accepting that no one lives forever, can save Iran.”

“Otherwise,” he warned, “what will remain is not your system, nor even our country — only a bitter ruin of a nation once called Iran.”

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The action targets entities linked to the Atomic Energy Organization of Iran (AEOI) and its subsidiary, the Iran Centrifuge Technology Company (TESA), both of which play key roles in Iran’s uranium enrichment and nuclear development efforts.

The Treasury’s Office of Foreign Assets Control (OFAC) designated the firms under Executive Order 13382, which aims to curb the proliferation of weapons of mass destruction.

"The Iranian regime’s reckless pursuit of nuclear weapons remains a grave threat to the United States and a menace to regional stability and global security," said Treasury Secretary Scott Bessent. “Treasury will continue to disrupt Iran’s nuclear advances and broader destabilizing agenda.”

Among those sanctioned is Atbin Ista Technical and Engineering Company (AIT), accused of aiding TESA’s acquisition of foreign components. AIT's managing director, Majid Mosallat, was also designated for acting on behalf of the company.

Also blacklisted are Pegah Aluminum Arak Company, which supplies aluminum products to TESA, and Thorium Power Company (TPC), established in 2023 to develop thorium-fueled reactor technologies under the guidance of AEOI.

The designations further include Pars Reactors Construction and Development Company (Satra Pars) and Azarab Industries Co., both of which are involved in AEOI-led nuclear projects, including reactor construction and equipment production.

As a result of the sanctions, all US-linked assets of the designated individuals and entities are frozen, and US persons are generally prohibited from conducting transactions with them. Secondary sanctions may apply to non-US persons engaging in certain activities with the listed entities.

The sanctions come amid heightened nuclear tensions and just days before talks between the United States and Iran are set to take place in Oman on Saturday.

The upcoming negotiations, to be led by Iranian Foreign Minister Abbas Araghchi and US envoy Steve Witkoff, were announced on Monday by President Donald Trump, who has repeatedly threatened Iran with military action if it does not agree to a deal since returning to the White House in January.

Former vice president Eshaq Jahangiri voiced support for ongoing talks between Iran and the United States, urging unity behind the country's negotiating strategy.

“At this stage, we must support these decisions, especially the policies the Supreme Leader has adopted,” he said on Wednesday.

Jahangiri also called for backing the negotiating team and warned against partisan moves that could weaken Iran’s broader diplomatic efforts.

Former deputy parliament speaker Ali Motahari called for the inclusion of senior current and former officials in Iran’s negotiating team with the United States, now led by Foreign Minister Abbas Araghchi.

“I suggest appointing Mr. Zarif, Salehi, Ali Larijani, and Takht-Ravanchi to the delegation to benefit from their experience and reach a fair agreement,” he wrote on X.

Javad Zarif is the architect of Iran’s 2015 nuclear deal and a former foreign minister; Ali-Akbar Salehi is a former head of the Atomic Energy Organization; Ali Larijani is a former parliament speaker; and Majid Takht-Ravanchi is currently deputy foreign minister for political affairs.