Richard Nephew, former US deputy special envoy for Iran during part of Joe Biden's presidency, said the level of trust between President Donald Trump and his special envoy Steve Witkoff augured well for the talks.
Still, as the negotiations are set for their third round on Saturday and first set of technical talks, the devil may be in the technical details.
"We haven't yet really seen a pretty clear sense of consistency or attention to detail on the technical side," he said in an interview with the podcast.
"Nuclear talks in general, but absolutely these, which have a 22-year history at this point, definitely could use a little bit more of the technical, a little more of the expert practitioner side," he added.
The ability of inspectors to understand and access the Iranian nuclear program which has advanced far further beyond levels reached when previous nuclear deal will also be key to success, Nephew said.