"That delusional fantasist claimed that Iran has been weakened," Khamenei told a group of his supporters in Tehran, without elaborating. "The future will reveal who has truly been weakened."
In the last week, US President Donald Trump, his predecessor Joe Biden and Israeli Prime Minister Benjamin Netanyahu, have all described Iran as weakened.
They cited Tehran's reduced influence in the region following the fall of its ally Bashar al-Assad's government in Syria, Israeli attacks on its air defense capabilities and the killing of leaders of its armed Palestinian and Lebanese allies.
Khamenei said former Iraqi dictator Saddam Hussein started the invasion of Iran in September 1980 and then-US president Ronald Reagan provided significant support to his regime, both "under the illusion that Iran was weak."
"They, along with dozens of other deluded individuals, ultimately met their demise, while the Islamic regime grew stronger day by day. I tell you, this experience will be repeated once again this time," he added.