"The change you're going to see is more focus on Iran," Mike Waltz, Trump's nominee to be US national security advisor, told CNBC in an interview.
"Maximum pressure, not only will it help stability in the Middle East, but it'll help stability in the Russia-Ukraine theater as well, as Iran provides ballistic missiles and literally thousands and thousands of drones that are going into that theater," he added.
The Republican congressman from Florida shares a strong pro-Israel and anti-Tehran stance with many of the incoming president's other top foreign policy picks.
In his last term, President Trump withdrew the United States from an international deal over Iran's disputed nuclear program and reimposed what his administration called a maximum pressure campaign against the Islamic Republic.
By ordering the assassination of a top Iranian military commander, Qassem Soleimani in Baghdad in 2020, Trump earned the lasting enmity of Iran's ruling military and clerical establishment which has repeatedly vowed revenge.
US investigators have alleged that the Islamic Revolutionary Guard Corps sought to enlist an Afghan national to assassinate Trump before the US election, in charges Iran denies.
The reimposition of harsh sanctions enforcement which had eased somewhat under President Joe Biden may herald a new era of confrontation between the United States in Iran as conflict between US ally Israel and armed Iranian fighters rages on.