Speaking on the sidelines of a cabinet meeting, Eslami said: “If the enemy makes even the slightest attack on our [nuclear] facilities, we will deliver a crushing response."
He told the cabinet that "our defense and security capabilities have always been prepared to confront such threats with vigilance".
Since at least 2010, Israel has allegedly conducted dozens of attacks inside Iran, targeting sensitive nuclear and military installations and carrying out assassinations of individuals deemed a threat.
The attacks became more frequent after July 2020, when a massive explosion occurred at the Natanz uranium enrichment site in central Iran, destroying one of the buildings.
In November that year, Mohsen Fakhrizadeh, a key figure in Iran’s nuclear program, was assassinated in a roadside attack near Tehran. Western and Israeli intelligence had long suspected Fakhrizadeh of being the architect of Iran’s covert nuclear weapons program.
Iran has long said its nuclear program is peaceful. The UN's nuclear chief, Rafael Grossi, said this year that Iran is "weeks not months" away from a nuclear weapon while a third of the UN's inspectors have been barred.
Eslami's latest warning comes as Israel prepares its retaliatory attack after the Islamic Republic launched 181 ballistic missiles towards Israel earlier this month.