The government of Pakistan condemned the killing of Hamas political leader Ismail Haniyeh, criticizing Israel's "adventurism in the region" and warning about the risk of further escalation.
In a statement, Pakistan's foreign ministry expressed "serious concern" over the increasing Israeli activities in the region, describing them as a "dangerous escalation in an already volatile region" that undermines peace efforts.
The ministry also censured the timing of what it called a "reckless act," noting that it coincided with the swearing-in of Iranian President Masoud Pezeshkian.
Also on Wednesday, Egypt condemned the recent strikes that targeted Hezbollah military leader Fuad Shukr in Beirut and Haniyeh in Tehran, describing them as a "dangerous escalation" that could destabilize the region.
The Egyptian foreign ministry stated that these actions undermine "the strenuous efforts made by Egypt and its partners to stop the war in the Gaza Strip" and "indicate the absence of Israeli political will to calm the situation."
Cairo has called on the United Nations Security Council to intervene to "prevent the security situation in the region from spiraling out of control."
Mohammad Javad Zarif, the former Iranian foreign minister, accused Israeli Prime Minister Benjamin Netanyahu of driving the region and the world “to the brink of catastrophe.”
In a statement on X, Zarif criticized the international community for “silently watching Israel's genocide, and repeated acts of international terrorism and aggression.”
He added that Netanyahu's survival depends on "death and destruction."
“The cowardly assassination of our guest will only strengthen our resolve to defend our territory and support the Palestinian people's fight for their freedom.”
Zarif urged the US and EU to stop “shielding Netanyahu's madness” and to join the world to end his "suicidal chaos."
Russia stated on Wednesday that the Middle East is teetering on the brink of a major war, with key players escalating tensions.
"The region is currently balancing on the brink of a global conflict," said Andrei Nastasin, deputy spokesman for the Russian foreign ministry. "The parties continue to raise the stakes."

Since at least 2010, Israel has allegedly conducted dozens of attacks inside Iran, targeting sensitive nuclear and military installations and carrying out assassinations of individuals deemed a threat.
These attacks became more frequent after July 2020, when a massive explosion occurred at the Natanz uranium enrichment site in central Iran, destroying one of the buildings. In November of that year, Mohsen Fakhrizadeh, a key figure in Iran’s nuclear program, was assassinated in a roadside attack near Tehran. Western and Israeli intelligence had long suspected Fakhrizadeh of being the architect of Iran’s covert nuclear weapons program.
Fakhrizadeh’s elimination rattled most echelons of the Iranian government, with different agencies subtly blaming one another for shortcomings that had led to the incident. It strengthened existing concerns that Israel had a strong network within Iran capable of using sophisticated weapons, having detailed information about the movement of key targets, and could pull off a complicated assassination and disappear without a trace.
However, spectacular attacks did not end with the killing of the top nuclear operative.

Since Fakhrizadeh’s assassination, which reportedly involved a high-tech, remote-operated machine gun, numerous small and large-scale attacks have continued to target various sites. While Israel has never acknowledged its involvement, it is widely believed that many incidents at military and industrial sites were the result of Israeli sabotage or drone attacks.
This latest attack occurred days after Iran’s Minister of Intelligence hailed the "dismantling of Mossad's infiltration network" as a pivotal achievement of former president Ebrahim Raisi's administration.
Esmail Khatib remarked last week, "Mossad's infiltration network had been assassinating our scientific figures and sabotaging critical centers. Under the thirteenth administration, this network and its access and capabilities have been eliminated."
Despite the persistent denials by Iranian officials, the series of targeted killings and sabotage reached such a critical point in 2021 that a former Minister of Intelligence, Ali Younesi, had expressed grave concern over the infiltration of Israel's intelligence agency, Mossad, into various sectors of the country, warning that officials should be "worried for their lives."

Younesi stated in 2021 that over the past "10, 15, or 20 years," while the country has been purged of all groups he labeled as "terrorist," there has been a significant failure in addressing the infiltration by foreign intelligence services, particularly those of Israel.
He emphasized that in the "last ten years, Mossad's infiltration into various sectors of the country is so extensive that all officials of the Islamic Republic should be worried for their lives."
In April 2021, another explosion at Natanz, this time in an underground part of the sprawling installation, hit the power supply for centrifuges and caused extensive damage that reportedly needed months of repairs. Some reports said that thousands of uranium enriching machines, called centrifuges, were destroyed.
Coupled with physical attacks, Israel allegedly launched many cyberattacks that created massive disruptions in Iran. In October 2021 a cyberattack knocked out a government database that issues fuel subsidized fuel cards to the population.
In May 2022, Revolutionary Guard intelligence operative Colonel Hassan Khodaei was shot five times outside of his home in Tehran. In May and June, following the assassination, two scientists reportedly died from poison in their food. Ayoub Entezari, an aerospace engineer, worked on missile turbines for a military research center in Yazd, central Iran.
Suicide drones were used to attack a military facility in Isfahan on January 28, 2023. Senior intelligence sources told Western media and that Israel’s Mossad was involved in the attack. It was reported that the site was an advanced weapon-production facility.
What is embarrassing and dangerous for the Iranian regime is the apparent extensive infiltration of Israeli networks in Iran. Ismail Haniyeh’s targeted killing on July 31 will go down in history as one of the most remarkable military-intelligence coups by Israel in the past eight decades.
A member of parliament from Lebanese armed group Hezbollah said on Wednesday that his group would be ready to fight a war with Israel, after an Israeli strike on the southern suburbs of Beirut targeted Hezbollah's top military commander.
Ali Ammar spoke to local broadcasters amid the ruins of Tuesday's strike.
"This enemy demands war and we are up for it, God willing, we are up for it," Ammar said.
The Tuesday airstrike killed Fuad Shukr, the "right-hand man" of Hezbollah Secretary-General Hassan Nasrallah who served as his adviser for planning and directing wartime operations, the Israel Defense Forces (IDF) said.
Kambiz Ghafouri, a journalist, commented on the circumstances surrounding the death of Ismail Haniyeh, stating that the attack demonstrates Israel's significant intelligence penetration in Iran, as it required meticulous planning days in advance.
Speaking to Iran International, Ghafouri mentioned that if the attack was carried out using guided drones within Iran, it implies that Israel has operational forces inside Iranian territory.
He added that if the airstrike was executed by precision-targeting fighter jets originating from another country, as some reports suggest, it would still indicate Israel's operational capabilities within Iran's borders.