Israel and Iran at war, Day 5: what we know so far

Here's a brief summary of major developments as the conflict entered its fifth day.

Trump's remarks on a US role

• Trump said the US and Israel had total control of Iran's skies.
• Trump called for Iran's unconditional surrender.
• Trump said the US knows where Iran's Supreme Leader is hiding but would not kill him for now.
• Trump said the US does not want missiles shot at civilians or US troops.
• Trump said the US patience was wearing thin.

Israel steps up attacks

• Israel ordered a Tehran district home to hundreds of thousands of people to evacuate.
• A huge explosion sent a mushroom cloud rising over eastern Tehran after Israeli airstrikes targeted the IRGC-affiliated Imam Hossein University as well as Khojir missile production complex.
• Multiple missile sites were struck in Isfahan, Israel said.
• Explosions and air defense activity were reported in Tehran, Karaj and Shiraz.
• Israel's military said 60 Israeli Air Force jets launched a major wave of strikes targeting Iranian missile launchers in the heart of Iran.