Aftermath of blasts near IRGC-linked university in Tehran after Israeli attack

Despite rising tensions between Iran and Israel, US negotiators continue to assess that Tehran is in a weakened position and could return to talks, ABC News reported on Wednesday, citing multiple officials involved in the diplomatic process.

The officials said Iran may ultimately agree to a deal requiring it to abandon all uranium enrichment, though the window for diplomacy remains narrow.

"If Iran returns to the negotiations and agrees to drop its uranium enrichment, US officials believe a high-level meeting led by Special Envoy Steve Witkoff and potentially Vice President JD Vance would happen as soon as this week," the report said.

President Donald Trump, monitoring the situation from the White House, has grown increasingly frustrated with what officials described as Tehran’s failure to provide clear signals about its intentions.

The Israeli military said on Wednesday it had carried out a series of overnight airstrikes on multiple military targets in the Tehran area, including a centrifuge production site and weapons manufacturing facilities.

According to the statement, over 50 Israeli Air Force fighter jets struck locations linked to Iran’s nuclear and missile programs, guided by military intelligence.

Among the targets was a site used to produce centrifuges for uranium enrichment, which the IDF said were intended to expand Iran’s capacity to develop nuclear weapons. The statement also added that several facilities producing components for surface-to-surface and surface-to-air missiles were hit, including materials used in attacks against Israel.

The strikes are part of what the IDF described as an ongoing effort to degrade Iran’s nuclear weapons program and its missile production capabilities.

Tabriz missile base

Storage buildings at Tabriz missile base

Tunnel opening at Tabriz missile base

Vehicle tunnel openings at Tabriz missile base

Storage buildings at Tabriz missile base

Aircraft at Mashhad airport

US President Donald Trump is considering joining Israel's attacks on Iranian nuclear facilities, CBS News reported citing US officials

Among the potential targets is the underground Fordow nuclear site, CBS cited sources including a senior intelligence official and a Department of Defense official as saying.

Here's a brief summary of major developments as the conflict entered its fifth day.

Trump's remarks on a US role

• Trump said the US and Israel had total control of Iran's skies.
• Trump called for Iran's unconditional surrender.
• Trump said the US knows where Iran's Supreme Leader is hiding but would not kill him for now.
• Trump said the US does not want missiles shot at civilians or US troops.
• Trump said the US patience was wearing thin.

Israel steps up attacks

• Israel ordered a Tehran district home to hundreds of thousands of people to evacuate.
• A huge explosion sent a mushroom cloud rising over eastern Tehran after Israeli airstrikes targeted the IRGC-affiliated Imam Hossein University as well as Khojir missile production complex.
• Multiple missile sites were struck in Isfahan, Israel said.
• Explosions and air defense activity were reported in Tehran, Karaj and Shiraz.
• Israel's military said 60 Israeli Air Force jets launched a major wave of strikes targeting Iranian missile launchers in the heart of Iran.
• Israeli attacks have so far killed 585 people and injured 1,326 in Iran, the human rights group HRANA reported.

Military ramp-up

• US warplanes departed a military base in England on Tuesday, the BBC reported.
• The United States is deploying additional fighter aircraft to the Middle East, Reuters reported.
• The US buildup includes F-22, F-16, and F-35 jets, one official said.
• Abdolrahim Mousavi, Chief of Staff of Iran’s Armed Forces called for the evacuation of Haifa and Tel Aviv after Israeli evacuation warnings for Tehran.
• The Islamic Revolutionary Guards' Aerospace Force targeted Israeli air bases.

Leaders weigh in

• French President Emmanuel Macron said any push to overthrow Iran’s government would bring chaos to the region.
• British Prime Minister Keir Starmer said he hoped for a de-escalation.
• Germany’s Chancellor Friedrich Merz praised Israel and said the outcome of the crisis was up to Tehran.
• Iran’s exiled crown prince Reza Pahlavi, an opposition leader, urged a nationwide uprising.